Study provides mechanistic insight into effects of regular coffee drinking on the brain’s network

A new study published in Molecular Psychiatry and sponsored by the Institute for Scientific Information on Coffee (ISIC), provides unique insights into the functional and connectivity changes that happen within the brain of regular coffee drinkers. This includes findings that when at rest, regular coffee drinkers had a reduced degree of connectivity in two areas of the brain (known as the right precuneus and right insular), indicating effects such as improved motor control and alertness (helping them to be better able to react to a stimulus), in comparison to non-coffee drinkers.

Patterns of more efficient connectivity were also found in other areas of the brain (including in the cerebellum and between the thalamus and the cerebellum), consistent with effects including improved motor control among regular coffee drinkers, compared to non-coffee drinkers.

Further findings included an increase in dynamic activity observed in several cerebellar and sub-cortical areas of the brain among regular coffee drinkers, consistent with effects including a reduction in mind wandering, increases in attention, alertness and arousal, and enhanced learning and memory. Put simply, these changes imply an improved ability to focus. These areas of the brain include the cerebellum, striatum, thalamus, parahipocampus, and the lingual and inferior occipital gyri.

Interestingly, the structural and connectivity differences observed among regular coffee drinkers in this research also occurred in non-coffee drinkers soon after they consumed a cup of coffee. This therefore indicates that coffee can impose these changes in a short time period, and that these effects are triggered by coffee.

The research was conducted by a team led by Professor Nuno Sousa, of the School of Medicine, University of Minho, Portugal. The researchers used technology called functional magnetic resonance imaging (fMRI), to compare the connectivity and structure of the brain of 31 regular coffee drinkers (who drink coffee everyday) and 24 non-coffee drinkers; while at rest, while performing a task, and soon after consuming a cup of coffee.

This is the first time that the effect of regular coffee drinking on the brain’s network has been studied in this level of detail. By using fMRI technology, we were able to observe the effect of coffee on the brain’s functional connectivity and structure, and the differences between regular coffee drinkers and non-coffee drinkers, in real-time. These findings have – at least in part – helped to provide a mechanistic insight for some of the effects observed in existing research on coffee; such as improved motor control, increased alertness, and benefits to learning and memory.”

Nuno Sousa, Professor of School of Medicine, University of Minho

The effect of caffeine and coffee on mental performance has been the subject of extensive research to date, with previous research demonstrating its effect in improving attention, alertness and arousal, motor control, and learning and memory. These new findings add to the body of research in this area, providing insights into the structural changes behind these effects.