Nanomaterial influences gut microbiome and immune system interactions

The nanomaterial graphene oxide — which is used in everything from electronics to sensors for biomolecules — can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden. The findings are reported in the journal Nature Nanotechnology.

“This shows that we must factor the gut microbiome into our understanding of how nanomaterials affect the immune system,” says the paper’s corresponding author Bengt Fadeel, professor at the Institute of Environmental Medicine, Karolinska Institutet. “Our results are important for identifying the potential adverse effects of nanomaterial and mitigating or preventing such effects in new materials.”

Graphene is an extremely thin material, a million times thinner than a human hair. It comprises a single layer of carbon atoms and is stronger than steel yet flexible, transparent, and electrically conductive. This makes it extremely useful in a multitude of applications, including in “smart” textiles equipped with wearable electronics and as a component of composite materials, to enhance the strength and conductivity of existing materials.

With the increased use of graphene-based nanomaterials comes a need to examine how these new materials affect the body. Nanomaterials are already known to impact on the immune system, and a few studies in recent years have shown that they can also affect the gut microbiome, the bacteria that naturally occur in the gastrointestinal tract.

The relationship between nanomaterial, gut microbiome and immunity has been the subject of the present study performed using zebrafish. The nanomaterial investigated was graphene oxide, which can be described as a relative of graphene that consists of carbon atoms along with atoms of oxygen. Unlike graphene, graphene oxide is soluble in water and of interest to medical research as, for example, a means of delivering drugs in the body.

In the study, the researchers exposed adult zebrafish to graphene oxide via the water and analysed how it affects the composition of the microbiome. They used both normal fish and fish lacking a receptor molecule in their intestinal cells called the aryl hydrocarbon receptor, commonly abbreviated as AhR, a receptor for various endogenous and bacterial metabolites.

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