Encapsulated Indian medicinal herb shows anti-diabetic properties in mice

Extracts of the herb Withania coagulans, or Paneer dodi, are used in traditional Indian medicine. Although some healers claim that W. coagulans can help treat diabetes, the bitter-tasting plant hasn’t been studied extensively by scientists. Now, researchers have found that herbal extracts packaged in polymers derived from natural substances can reduce blood glucose levels in diabetic mice. They report their results in ACS Omega.

Alternative medicines are becoming increasingly popular for the treatment of chronic illness, primarily because of people’s perception that plant-based medicines are less toxic and have fewer side effects. However, this is not always the case, and even so-called “natural” therapies must be carefully tested for efficacy, dose-related toxicity and interactions with other drugs. In addition, scientists must find ways to effectively deliver the medicines into the body in controlled ways. Many plant extracts, like W. coagulans, are bitter and unpalatable at the doses needed to have beneficial effects. Also, when taken orally, the medicinal components in plant extracts are often destroyed by the acidic conditions of the stomach. That’s why Say Chye Joachim Loo and colleagues wanted to find a way to encapsulate W. coagulans extract in a delivery system based on natural components that could safely transport the extract to the small intestine, where the cargo would be released and absorbed.

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