ACP offers guidance on the ethical use of genetic testing and precision medicine

A new position paper from the American College of Physicians (ACP) offers guidance regarding ethical decision-making for the integration of precision medicine and genetic testing into internal medicine. ACP’s advice is published in Annals of Internal Medicine.

The paper was developed by ACP’s Ethics, Professionalism and Human Rights Committee in response to the issue of rapid advances in genome sequencing technology that have generated a range of genetic testing technologies that can contribute to precision medicine. Like many new technologies, these testing approaches have the potential to improve health care but can pose ethical questions. The position paper states that:

• As with any medical testing, genetic testing should be guided by the best interests of the patient, scientific evidence, and ethical standards. Testing must be clinically indicated for the patient and consideration must be given to whether the results of the test will affect clinical decision-making. The benefits of genetic testing are greatest when it is used to answer an actionable clinical question and the findings can be translated into treatment recommendations.
• Physicians should engage with patients in discussions about the opportunities and ethical challenges of genetic testing and precision medicine.
• Physicians can assist patients in understanding the risks, benefits, and uncertainty of direct-to-consumer genetic medical testing. ACP discourages the use of direct-to-consumer genetic medical testing and advises that testing should be done in the context of a patient-physician relationship, with appropriate counseling.
• Genetic testing raises new challenges for privacy and the use and protection of patient information.

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